Mucuna pruriens Protects against MPTP Intoxicated Neuroinflammation in Parkinson’s Disease through NF-κB/pAKT Signaling Pathways
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چکیده
منابع مشابه
Mucuna pruriens Protects against MPTP Intoxicated Neuroinflammation in Parkinson’s Disease through NF-κB/pAKT Signaling Pathways
Till date, drugs that have been used to manage Parkinson's disease (PD) have only shown symptomatic relief with several adverse effects besides their inability to prevent neurodegeneration. Neuroinflammation plays an important role in the advancement of PD and can be targeted for its effective treatment. Researchers have suggested that herbal plants exhibiting the anti-inflammatory and anti-oxi...
متن کاملMucuna pruriens in Parkinson disease
OBJECTIVE To investigate whether Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in all tropical areas worldwide, may be used as alternative source of levodopa for indigent individuals with Parkinson disease (PD) who cannot afford long-term therapy with marketed levodopa preparations. METHODS We investigated efficacy and safety of single-dose intake of MP powder from roas...
متن کاملNeuroprotective Effects of Mucuna pruriens Against Stress-Induced Oxidative Damage
Stress is known to alter the cellular homeostasis by oxidative damage in brain which in turn involves in various forms of neurotoxicity including neuronal death. The seed powder of the leguminous plant, Mucuna pruriens (MP) has long been used in traditional Ayurvedic Indian medicine for various neurological diseases including Parkinsonism. The neuroprotective and neurorestorative effect of MP w...
متن کاملThe Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate
Chronic treatment with levodopa (LD) in Parkinson's disease (PD) can cause drug induced dyskinesias. Mucuna pruriens endocarp powder (MPEP) contains several compounds including natural LD and has been reported to not cause drug-induced dyskinesias. We evaluated the effects of Mucuna pruriens to determine if its underlying mechanistic actions are exclusively due to LD. We first compared MPEP wit...
متن کاملComparative evaluation of extract of Bacopa monnieri and Mucuna pruriens as neuroprotectant in MPTP model of Parkinson’s disease
Parkinson’s disease (PD) results primarily from the death of dopaminergic neurons in substantia nigra. Treatment of PD has been shifted recently towards herbal medicines. Bacopa monnieri (L.) Wettst. (BM) and Mucuna pruriens (L.) DC (MP) are traditional herbal plants known to have neuroprotective effects due to the presence of bacosides in whole plant extract of Bacopa monnieri (BME) and L-DOPA...
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ژورنال
عنوان ژورنال: Frontiers in Aging Neuroscience
سال: 2017
ISSN: 1663-4365
DOI: 10.3389/fnagi.2017.00421